Prolia Denosumab Injection: Side Effects, Uses, Dosage, Interactions, Warnings

Spread the love

These types of medications come in forms that are taken by mouth and forms that are given by injection. Prolia contains the active drug denosumab, and Reclast contains the active drug zoledronic acid. Both medications are approved to treat certain people with osteoporosis, as well as people with other conditions. Yes, your risk for bone fractures is higher if you leave osteoporosis untreated.

  1. In women of reproductive potential, pregnancy testing should be performed prior to initiating treatment with Prolia [see Use In Specific Populations].
  2. To learn how you’ll receive Prolia doses, see “How it’s administered” below.
  3. The significance of these findings and the effect of long-term treatment with Prolia are unknown.
  4. The following table lists some of the more commonly reported mild side effects of Evenity and Prolia.

For these reasons, comparison of antibodies to denosumab with the incidence of antibodies to other products may be misleading. Epidermal and dermal adverse events (such as dermatitis, eczema, and rashes) were reported in 4 patients (3.3%) in the placebo group and 5 patients (4.2%) in the Prolia group. ONJ has been reported in the osteoporosis clinical trial program in patients treated with Prolia [see WARNINGS AND PRECAUTIONS]. The recommended dose of Prolia is 60 mg administered as a single subcutaneous (under the skin) injection once every 6 months. If you need to stop receiving Evenity earlier than 12 months, your doctor may also recommend switching to Prolia to treat your osteoporosis.

Alternatives to Prolia injection

To learn how you’ll receive Prolia doses, see “How it’s administered” below. Your doctor will recommend the dosage of Prolia that’s right for you. Below are commonly used dosages, but the dosage you receive will be determined by your doctor. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet.

What drugs and food should I avoid while taking Prolia (Denosumab (Prolia))?

With steroid-induced osteoporosis, your bones become thin and weak from using certain corticosteroids. It’s FDA-approved to reduced bone loss and to treat osteoporosis (a condition that xanax side effects causes weakened bones). Consistent effects on BMD were observed at the lumbar spine in relevant subgroups defined by baseline age, BMD, and baseline history of vertebral fracture.

How long do side effects of Prolia last?

American Association of Clinical Endocrinologists (AACE) guidelines recommend both Evenity and Prolia as treatment options for this use. For details about the uses of these drugs, see our in-depth articles on Evenity and Prolia. If your doctor suggests treatment with Evenity or Prolia, you may also wonder about other options for treating your condition. In addition to boxed warnings, Evenity and Prolia have other warnings.

A total of 725 men were exposed to placebo and 731 men were exposed to Prolia administered once every 6 months as a single 60 mg subcutaneous dose. All men were instructed to take at least 1000 mg of calcium and 400 IU of vitamin D supplementation per day. In clinical trials, Prolia was an effective crack cocaine symptoms and warning signs treatment to increase bone mass in males taking certain medications that decrease androgen levels. Some males were given injections of Prolia, while other males were given injections of a placebo (no active drug). In this study, BMD was measured to evaluate how strong the males’ bones were.

Weight gain itself wasn’t reported as a side effect during clinical trials of Prolia. However, some people taking Prolia did have swelling in their arms or legs. And with swelling, your body weight can be quickly increased.

With these reports, it wasn’t known whether Prolia or something else (such as a different medication) caused the hair loss. The list below may not include all possible serious side effects of the drug. The sections above describe the typical dosage provided by the drug’s manufacturer. If your doctor recommends Prolia for you, they’ll prescribe the dosage that’s right for you. But in certain rare situations, your doctor may decide you can give yourself Prolia injections at home.